Calcium antagonists and endothelial function
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منابع مشابه
High blood pressure and endothelial dysfunction: effects of high blood pressure medications on endothelial dysfunction and new treatments
Hypertension is one of the most common chronic medical conditions and to this day has remained one of the important problems of public health. Because of relationship between endothelial dysfunction, atherosclerosis and high blood pressure, returning the endothelium-dependent vasodilatation is known as one of the important goals of treatment for high blood pressure. Drugs should be able to pres...
متن کاملA QUANTUM CHEMICAL STUDY OF STRUCTURE -ACTIVITY RELATIONSHIPS OF DIHYDROPYRIDINE CALCIUM ANTAGONISTS
Quantum chemical (MNDo)caleulations have beenused toelucidate the molecular properties and structure - activity relationships of dihydropyridine (DHP) type calcium antagonists. There is a good corielation between the net atomic charges on various atoms of the 4 - phenyl ring of dihydropyridines and pharmacological activity. .Also, activity decreases with increasing free rotation of the phen...
متن کاملThe Antiiflammtory Activity of calcium-channel antagonists on chronic inflammation in rat
calcium mobilization is known to be an important factor in the activation of cells involved in inflammation,so,calcium-channel antagonists are be expected ti exhibit antiinflammatory activity.in the present study,we evaluateted the antiinflammatory effects of two calcium channel blockers,verapamil and nifedipine on adjuvant induced chronic in flammation in rat paw.sixty adult male rats were div...
متن کاملEndothelial Vasodilator Angiotensin Receptors are Changing in Mice with Ageing
Background: The vascular function of Angiotensin II-type-2 receptors in adults is controversial. We sought their location and function in mouse aortic rings at young and old mice. Materials and Methods: Male C57Bl mice (aged 4 and 14 months) were killed by CO2. The descending thoracic aorta was cleaned and dissected into rings. Aortic rings were mounted in Krebs’ solution at 37 °C an...
متن کاملAn antioxidant role for calcium antagonists in the prevention of adrenaline mediated myocardial and endothelial damage.
OBJECTIVE To investigate the mechanism of calcium antagonist mediated cytoprotection against the damaging effects of adrenaline in vivo on cardiac myocytes and human endothelial cells from the umbilical vein. METHODS Human endothelial cells cultured from the umbilical vein and isolated rat cardiac myocytes were treated with plasma from rats given adrenaline 30 minutes previously with pretreat...
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